Why Susan From The Blacklist Looks So Familiar

A year after X2: X-Men United hit theaters, Janssen landed a recurring role in the second season of FX's medical drama Nip/Tuck. She made her debut as life coach Ava Moore in the third episode of the season, "Manya Mabika," in which she convinced Julian McMahon's Dr. Christian Troy to resolve his issues with Joely Richardson's Julia McNamara.

Janssen's arc on Nip/Tuck would have been disappointing if it ended there, but it didn't. She was, for all intents and purposes, the primary antagonist of the season. Her stint on the series involved antagonism, manipulation, and seduction. While that's extreme in and of itself, her story is all the more interesting when audiences discover she's a transsexual.

She used to be a homosexual male, but thanks to reconstructive surgery, she is now considered "the Hope Diamond of Transsexuals; completely flawless in every way," according to Christian. Being a transsexual plays an integral part of her arc, which unfolds across multiple seasons.